Condensin function in dosage compensation
نویسندگان
چکیده
منابع مشابه
Condensin-Driven Remodeling of X-Chromosome Topology during Dosage Compensation
Sample Name Wild-Type replicate 1 Wild-Type replicate 2 DC Mutant replicate 1 DC Mutant replicate 2 Total Reads 266,503,508 215,734,234 151,418,128 191,241,617 Side 1 Aligned 220,076,203 174,029,683 128,872,247 160,622,937 Side 2 Aligned 199,932,153 152,253,096 121,293,537 149,367,839 Both Sides Aligned 186,500,411 147,325,957 114,228,910 140,682,829 Same Fragment 86,672,650 60,980,725 39,616,4...
متن کاملCondensin controls recruitment of RNA polymerase II to achieve nematode X-chromosome dosage compensation
The X-chromosome gene regulatory process called dosage compensation ensures that males (1X) and females (2X) express equal levels of X-chromosome transcripts. The mechanism in Caenorhabditis elegans has been elusive due to improperly annotated transcription start sites (TSSs). Here we define TSSs and the distribution of transcriptionally engaged RNA polymerase II (Pol II) genome-wide in wild-ty...
متن کاملA condensin-like dosage compensation complex acts at a distance to control expression throughout the genome.
In many species, a dosage compensation complex (DCC) is targeted to X chromosomes of one sex to equalize levels of X-gene products between males (1X) and females (2X). Here we identify cis-acting regulatory elements that target the Caenorhabditis elegans X chromosome for repression by the DCC. The DCC binds to discrete, dispersed sites on X of two types. rex sites (recruitment elements on X) re...
متن کاملDosage compensation in mammals.
Many organisms show major chromosomal differences between sexes. In mammals, females have two copies of a large, gene-rich chromosome, the X, whereas males have one X and a small, gene-poor Y. The imbalance in expression of several hundred genes is lethal if not dealt with by dosage compensation. The male-female difference is addressed by silencing of genes on one female X early in development....
متن کاملDosage compensation in birds
The Z and W sex chromosomes of birds have evolved independently from the mammalian X and Y chromosomes [1]. Unlike mammals, female birds are heterogametic (ZW), while males are homogametic (ZZ). Therefore male birds, like female mammals, carry a double dose of sex-linked genes relative to the other sex. Other animals with nonhomologous sex chromosomes possess "dosage compensation" systems to eq...
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ژورنال
عنوان ژورنال: Epigenetics
سال: 2009
ISSN: 1559-2294,1559-2308
DOI: 10.4161/epi.8957